Over-the-counter (OTC) pain relief medications are a convenient and effective way to manage various types of pain, from headaches to muscle soreness. However, not all pain relievers are created equal, and some are better suited for specific circumstances than others. Certain medications may not be safe for everyone, depending on their health conditions and other factors. Let’s explore the most common OTC pain relievers, discuss what circumstances they are best for, and highlight who should avoid certain types of medications.

Acetaminophen (Tylenol)

This is a great medication for headaches, fever, and minor aches and pains. If you have a toothache, menstrual cramps, muscle aches, reach for the acetaminophen bottle.

Acetaminophen works by blocking the production of prostaglandins in the brain, which are chemicals responsible for pain and fever. It is not an anti-inflammatory, so it’s less effective for pain caused by inflammation, such as arthritis.

This medication is not ideal for:

  • People with liver disease: Acetaminophen is processed by the liver, so those with liver conditions or heavy alcohol users should avoid or limit its use.
  • Individuals taking other medications containing acetaminophen: Many cold and flu medications also contain acetaminophen, so it’s essential to avoid exceeding the recommended daily dose (usually 3,000 to 4,000 mg per day) to prevent liver damage.

Ibuprofen (Advil, Motrin)

If you are needing to relieve muscle aches, back pain, arthritis, menstrual cramps, headaches, toothaches, or fever, ibuprofen can provide some relief.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by blocking the production of prostaglandins throughout the body. It is particularly effective for pain associated with inflammation, such as sprains, strains, and arthritis.

Who Should Avoid It:

  • People with stomach ulcers or gastrointestinal issues: Ibuprofen can irritate the stomach lining and increase the risk of ulcers and gastrointestinal bleeding.
  • Individuals with kidney disease: Ibuprofen can affect kidney function, so those with pre-existing kidney conditions should avoid it.
  • People with heart disease or high blood pressure: NSAIDs like ibuprofen can increase the risk of heart attack or stroke, particularly when used long-term or in high doses.
  • Pregnant women, especially in the third trimester: Ibuprofen can affect fetal development and should generally be avoided during pregnancy unless recommended by a healthcare provider.

Naproxen (Aleve)

Naproxen is recommended for those looking to relieve symptoms from arthritis, muscle aches, back pain, menstrual cramps, tendonitis and fever.

Like ibuprofen, naproxen is an NSAID that works by reducing inflammation, pain, and fever. It has a longer duration of action, so it can be taken less frequently (usually every 8 to 12 hours) compared to ibuprofen.

If you have the following conditions, you should avoid naproxen:

  • People with stomach ulcers or gastrointestinal issues: Naproxen, like other NSAIDs, can irritate the stomach lining and increase the risk of ulcers and gastrointestinal bleeding.
  • Individuals with kidney disease: Naproxen can affect kidney function, so it should be avoided by those with kidney problems.
  • People with heart disease or high blood pressure: Naproxen carries similar cardiovascular risks as ibuprofen and should be used cautiously in individuals with heart conditions.
  • Pregnant women, especially in the third trimester: As with other NSAIDs, naproxen should generally be avoided during pregnancy.

Aspirin (Bayer, Bufferin)

Aspirin is often recommended for prevention purposes like preventing heart attacks and strokes. It also has anti-inflammatory purposes and can be also used for mild pain relief and fever reduction.

Aspirin is another NSAID that reduces pain, inflammation, and fever. It also has blood-thinning properties, which is why it’s often used in low doses to prevent heart attacks and strokes.

Although aspirin has some great benefits, the following people should avoid it:

  • Children and teenagers with viral infections: Aspirin should never be given to children or teenagers with flu-like symptoms or chickenpox due to the risk of Reye's syndrome, a rare but serious condition.
  • People with stomach ulcers or gastrointestinal issues: Aspirin can irritate the stomach and increase the risk of ulcers and gastrointestinal bleeding.
  • Individuals with bleeding disorders: Aspirin’s blood-thinning effects can exacerbate bleeding problems, so it should be avoided by those with bleeding disorders or those on anticoagulant medications.
  • People with asthma: Aspirin can trigger asthma attacks in some individuals, particularly those with aspirin-exacerbated respiratory disease (AERD).

Topical Pain Relievers (Creams, Gels, Patches)

In addition to oral medication, there are topical pain relievers that can be used to target specific areas. This is best used for localized muscle or joint pain, arthritis, or minor sprains or strains.

Topical pain relievers, such as those containing menthol, camphor, or capsaicin, are applied directly to the skin over the affected area. They provide temporary pain relief by numbing the area, reducing inflammation, or interfering with pain signals.

This is a great tool to have as you look to reduce pain, but should be avoided by:

  • People with skin allergies or sensitivities: Some individuals may experience skin irritation, redness, or an allergic reaction to certain topical ingredients.
  • Individuals with open wounds or broken skin: Topical pain relievers should not be applied to open wounds or broken skin, as this can lead to irritation or absorption into the bloodstream.

Over-the-counter pain relief medications can be highly effective for managing various types of pain, but it’s crucial to choose the right one for your specific needs and health conditions. Understanding the benefits and risks of each type of pain reliever can help you make informed decisions and avoid potential complications. Always follow the recommended dosages and consult with a healthcare provider if you have any concerns, especially if you have underlying health conditions or are taking other medications. By using OTC pain relievers safely and appropriately, you can effectively manage pain and maintain your overall well-being.

College Park Pharmacy, Howard’s Pharmacy, Mooney’s Pharmacy, P&S Pharmacy, and Mossy Creek Pharmacy are independent pharmacy businesses in East Tennessee that pride themselves in customer service. We want to gain your trust as part of your medical team and build a relationship with you. We strive to put patients first and help you improve your health. Please come by and see us.